Controlled cultivation – reliable therapy
Chinese medicinal plants from Bavaria

Collage of various Chinese medicinal herbs
The use of medicinal plants plays an essential role in Traditional Chinese Medicine (TCM). It was in 1999 that our interdisciplinary research group dedicated itself to the establishment of the controlled production of selected Chinese medicinal herbs in Germany. This resulted in the availability of reliable quality TCM herbs.
The work was based on the confirmation of the botanical identity, as well as on the development of suitable cultivation and processing standards. The yield and constituent contents of some species are improved by plant breeding. In a number of pharmaceutic studies and therapeutic observations the quality and efficacy of the herbal remedies was analyzed.
Consequently, in 2005 this interdisciplinary research led to the field cultivation of several Chinese medicinal plant species and to high quality materia medica from Bavaria. The certified herbal remedies are distributed via retailers and pharmacies.
Various Chinese medicinal herbs
The research work in the field, lab and medicinal practice is conducted by the Bavarian State Research Center for Agriculture (LfL; project leader), the Ludwig-Maximilians-Universität München, the Universität Graz, the companies PhytoLab GmbH & Co. KG and Kräuter Mix GmbH, as well as the medical associations DECA (Association for the Documentation of Empirical Knowledge of Chinese Herbal Therapy DECA GmbH) and SMS (International Society of Chinese Medicine). Meanwhile after 16 years of research, the interdisciplinary consortium with its networking in the international context of TCM has developed a unique expertise covering all fields from botany through cultivation and processing to the patient.
This knowledge will be focused and further developed in the Center of Competence for Chinese Medicinal Plants.

Interconnected research

Cultivation studies and breeding
Up to now, more than 20 species of Chinese medicinal plants have been tested for cultivation and processing techniques, harvest times and different seed sources. Seed, which has had its botanical identity approved, together with information of production standards have been released to seed multipliers and farmers for regional production of Chinese medicinal plants ( The available seed sources are mostly heterogeneous populations and do sometimes cause problems in cultivation. Out of these populations, suitable plant types have been selected for crop improvement. The main breeding goals are homogeneity, high and reliable yields, high constituent contents, improved seed quality and plant health or reliable survival after the Central European winter conditions. Artemisia scoparia, Astragalus mongholicus, Bupleurum chinense, Leonurus japonicus, Salvia miltiorrhiza and Saposhnikovia divaricata are part of the breeding program.
Commercial GAP cultivation in Bavaria
Green field of Sigesbeckia pubescens
At present, 10 Chinese plant species are commercially produced in Bavaria. The farmers who produce these species are greatly experienced and professionally equipped for medicinal plant production. Several samples of the plants and their materia medica are as follows:
Artemisia scoparia , Yinchen, 茵陈 Virgate wormwood
Leonurus japonicus , Yimucao, 益母草 Chinese motherwort
Saposhnikovia divaricata , Fangfeng, 防风 Saposhnikovia
  • Angelica dahurica
  • Astragalus mongholicus
  • Paeonia lactiflora (Radix rubra)
  • Salvia miltiorrhiza
  • Scutellaria baicalensis
  • Sigesbeckia pubescens
  • Xanthium sibiricum
Botanical Identification
The botanical taxon of each plant species and seed source under agricultural experimentation must be precisely identified. The basic tool is the analysis of DNA sequences reconfirmed by the morphological and chemical characters of the plants. This is the guarantee for the secure identity of TCM materia medica from Bavarian cultivation.
Compositional analysis
The pharmaceutical quality must be safely reached by the domestic herbs in accordance to the Chinese and European pharmacopoeia. Therefore, the accessions were analyzed depending on the growing, harvesting and processing methods for their level of constituents. The analysis methods had to be adapted or newly developed for certain species, e.g. Radix Astragali and Fructus Xanthii .
Assurance of purity
Besides the constituents, the reduction of harmful substances plays an important role. For example, certain species such as Artemisia accumulate cadmium. The use of certain seed sources and fertilizer can assist in the reduction of cadmium accumulation in this species.
The naturally occurring of microorganisms on the fruits of Xanthium could be reduced by higher drying temperatures. Tests showed that the classic roasting of Fructus Xanthii in a wok may not lead to the complete degradation of the toxin carboxyatractyloside, which naturally occurs in Xanthium fruits. Therefore, key parameters for effective detoxification of Xanthium were elaborated.
Assessment by laboratory, pharmacists and doctors
The quality of domestic drugs and Chinese commercial import was compared for their pharmaceutical and sensory quality. The fresh aroma, purity and high level of constituents of the domestic drugs was highly satisfactory. The clinical testing as part of an observational study was positive. Therefore, the use of the TCM herbs produced in Bavaria can be recommended.
Pharmacists are used to the outside appearance of TCM herbs imported from Asia. Therefore, it is important to inform the wholesalers and pharmacists about the good quality and safety of domestic materia medica even if they differ visually. An additional aim of the project is to establish a standardized slicing for root drugs.
The interdisciplinary team of researchers is contributing in national and international committees, e.g. in expert groups of the EDQM (European Directorate for the Quality of Medicines and Healthcare) and the German Pharmacopoeia Commission. The findings of the project are incorporated in the preparation of monographs for the German and European Pharmacopoeia.

Advantages of locally grown TCM herbs

TCM herbs produced in Germany have the great advantage of being grown in a controlled and completely documented cultivation according to the GAP guidelines and restrictive European legislation. Pesticides are not permitted for use in the production of TCM herbs in Germany. In fact, some of the herb growers are even certified organic farmers. Thus, patients can be treated safely with this materia medica. Quality assurance and standardization are the strengths of the herbal remedies produced in Germany. They meet the official requirements of the German and European pharmacopoeia. As a result, the use of locally produced TCM herbs has been recommended by renowned TCM doctors.